Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 11/20 | 0.44 |
| ▸ | HTR1B | P28222 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831800 | 0.88 | HTR1A (0.57) | HTR1AHTR2CHTR1DHTR1BLMNA | |
| SCHEMBL27343955 | 0.86 | HTR1A (0.53) | HTR1AHTR2CHTR1DHTR1BLMNA | |
| SCHEMBL8784342 | 0.84 | HTR1A (0.53) | HTR1AHTR2CHTR1DHTR1BGABRP | |
| SCHEMBL9545340 | 0.81 | HTR1A (0.41) | HTR1AHTR2CHTR1DHTR1BOPRK1 | |
| SCHEMBL9087213 | 0.79 | HTR1A (0.42) | HTR1AHTR2CLMNAL3MBTL1FLT3 | |
| SCHEMBL9086672 | 0.76 | HTR1A (0.59) | HTR1AHTR2CHTR1DHTR1BLMNA | |
| SCHEMBL8883273 | 0.75 | HTR1A (0.76) | HTR1AHTR2CHTR1DHTR1BCYP1A2 | |
| SCHEMBL8783856 | 0.73 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1B | |
| SCHEMBL8783749 | 0.70 | GABRP (0.56) | HTR1AHTR2CHTR1DHTR1BGABRP | |
| SCHEMBL7836170 | 0.69 | HTR1A (0.58) | HTR1AHTR2CHTR1DHTR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630374-B1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 2001-09-05 | — | — | EP | disclosed |