Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCKAR | P32238 | 4/20 | 0.37 |
| ▸ | CCKBR | P32239 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.37 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777438 | 0.86 | GPR132 (0.43) | GPR132HSD17B10LMNASMN1; SMN2KMT2A | |
| SCHEMBL7835935 | 0.84 | SUCNR1 (0.45) | — | |
| SCHEMBL6778181 | 0.82 | GPR132 (0.45) | GPR132HSD17B10KMT2ACMKLR2CMKLR1 | |
| SCHEMBL6774904 | 0.78 | GPR132 (0.47) | GPR132CMKLR2CMKLR1FOLH1 | |
| SCHEMBL7835830 | 0.73 | ITGB3 (0.47) | KMT2A | |
| SCHEMBL7341395 | 0.72 | MEN1 (0.42) | GPR132HSD17B10KMT2ACMKLR2CMKLR1 | |
| SCHEMBL6778020 | 0.72 | ITGB3 (0.48) | KMT2A | |
| SCHEMBL6777425 | 0.70 | SUCNR1 (0.45) | — | |
| SCHEMBL6777155 | 0.69 | ITGB3 (0.48) | KMT2A | |
| SCHEMBL7836758 | 0.69 | NLRP3 (0.41) | GPR132KMT2ACMKLR2CMKLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |