Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5982029 | 0.94 | MAOA (0.37) | ALDH1A1KDM4ELMNAHPGDNPC1 | |
| SCHEMBL5981819 | 0.79 | SLC9A1 (0.50) | TP53MAPTSMN1; SMN2SLC9A1TDP1 | |
| SCHEMBL9228815 | 0.76 | USP2 (0.38) | ALDH1A1KDM4ELMNAHPGDNPC1 | |
| SCHEMBL5982299 | 0.74 | ATM (0.41) | ALDH1A1KDM4ELMNAHPGDNPC1 | |
| SCHEMBL5373386 | 0.74 | SLC9A1 (0.51) | ALDH1A1TP53MAPTSMN1; SMN2SLC9A1 | |
| SCHEMBL7267292 | 0.73 | SLC9A1 (0.53) | ALDH1A1TP53MAPTSMN1; SMN2SLC9A1 | |
| SCHEMBL5983792 | 0.73 | SLC9A1 (0.53) | ALDH1A1TP53MAPTSMN1; SMN2SLC9A1 | |
| SCHEMBL8484476 | 0.70 | RPS6KA5 (0.37) | ALDH1A1KDM4ELMNAHPGDNPC1 | |
| SCHEMBL7837678 | 0.69 | ASAH1 (0.38) | ALDH1A1KDM4ELMNAMAPTSLC9A1 | |
| SCHEMBL1828029 | 0.68 | SLC9A1 (0.47) | ALDH1A1KDM4ELMNAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676398-B1 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-1022274-A1 | Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |