Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.52 |
| ▸ | ITGAV | P06756 | 19/20 | 0.52 |
| ▸ | ITGB6 | P18564 | 16/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.43 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.43 |
| ▸ | ITGA8 | P53708 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834703 | 0.90 | ITGB3 (0.48) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7346550 | 0.90 | ITGB3 (0.40) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6772684 | 0.88 | ITGB3 (0.64) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7823382 | 0.87 | MAPT (0.41) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7340341 | 0.86 | F7 (0.41) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7836365 | 0.86 | ITGB3 (0.52) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7344055 | 0.85 | F7 (0.46) | MAPT | |
| SCHEMBL7340506 | 0.84 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7340065 | 0.84 | F7 (0.38) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL3839471 | 0.83 | GPR139 (0.47) | ITGB3ITGAVITGB1ITGA5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |