Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775429 | 0.88 | ITGB3 (0.44) | KMT2AMEN1GPR139ITGB3ITGA2B | |
| SCHEMBL7343613 | 0.88 | KMT2A (0.39) | NPSR1KMT2AMEN1GPR139ALDH1A1 | |
| SCHEMBL7345100 | 0.88 | NPSR1 (0.43) | NPSR1KMT2AMEN1GPR139ALDH1A1 | |
| SCHEMBL6779650 | 0.87 | GPR139 (0.43) | KMT2AMEN1GPR139ALDH1A1F2 | |
| SCHEMBL3839471 | 0.86 | GPR139 (0.47) | KMT2AMEN1GPR139F2ITGB3 | |
| SCHEMBL7343772 | 0.86 | HTT (0.41) | NPSR1KMT2AMEN1GPR139ALDH1A1 | |
| SCHEMBL7349391 | 0.86 | ITGB3 (0.56) | NPSR1KMT2AMEN1GPR139ALDH1A1 | |
| SCHEMBL7349404 | 0.86 | ITGB3 (0.56) | NPSR1KMT2AMEN1GPR139ALDH1A1 | |
| SCHEMBL7341927 | 0.86 | ITGB3 (0.56) | NPSR1KMT2AMEN1GPR139ALDH1A1 | |
| SCHEMBL7341726 | 0.85 | GPR139 (0.42) | NPSR1KMT2AMEN1GPR139ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| CN-1201454-A | Meta-guanidino, ureido, thioureido or azacyclic aminobenzoic acid derivatives as integrin antagonists | SEARLE & CO (US) | 1998-12-09 | — | — | CN | claimed |