Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 8/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 8/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 7/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836234 | 1.00 | MEN1 (0.45) | MEN1KMT2AP2RX7HPGDPLAAT5 | |
| SCHEMBL6161533 | 0.83 | PLAAT3 (0.37) | KMT2AHPGDPLAAT5PLAAT4PLAAT3 | |
| SCHEMBL6161539 | 0.83 | PLAAT3 (0.37) | KMT2AHPGDPLAAT5PLAAT4PLAAT3 | |
| SCHEMBL11778569 | 0.80 | MAPT (0.45) | MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7494539 | 0.79 | L3MBTL1 (0.44) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6975399 | 0.78 | ALDH1A1 (0.36) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6153056 | 0.76 | BACE1 (0.40) | MEN1KMT2AHPGDPLAAT5PLAAT4 | |
| SCHEMBL6153057 | 0.76 | BACE1 (0.40) | MEN1KMT2AHPGDPLAAT5PLAAT4 | |
| SCHEMBL991969 | 0.75 | ALDH1A1 (0.57) | PLAAT5PLAAT4PLAAT3PLAAT2ALDH1A1 | |
| SCHEMBL6153271 | 0.75 | PLAAT3 (0.34) | MEN1KMT2AHPGDPLAAT5PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790239-B1 | Novel 4-phenyl-2-(piperazinyl/perhydrodiazepinyl/aminoalkyl)carbonylmethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid derivatives as bradykinin receptor antagonists | PFIZER (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-0777653-B1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5861402-A | BRADYKININ ANTAGONISTS USEFUL FOR THE TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, COMMON COLD, ALLERGIES, ASTHMA, PANCREATITIS, BURNS, VIRUS INFECTION, HEAD INJURY, MULTIPLE TRAUMA | PFIZER PHARMACEUTICALS, INC. (JP) | 1999-01-19 | — | — | US | disclosed |
| US-5859011-A | Dihydropyridine derivatives as bradykinin antagonist | PFIZER INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0790239-A1 | Novel 4-phenyl-2-(piperazinyl/perhydrodiazepinyl/aminoalkyl)carbonylmethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid derivatives as bradykinin receptor antagonists | PFIZER INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| EP-0777653-A1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006083-A1 | 2-(PIPERAZINYL-1-CARBONYLMETHYL)-1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |
| WO-1996006082-A1 | DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1996-02-29 | — | — | WO | disclosed |