Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.42 |
| ▸ | F7 | P08709 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.39 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.39 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6779037 | 0.91 | MAPK1 (0.48) | PKMHTTLMNAMAPK1GPR139 | |
| SCHEMBL3839471 | 0.91 | GPR139 (0.47) | GPR139ITGB3ITGA2BKMT2AF2 | |
| SCHEMBL7339495 | 0.89 | KMT2A (0.44) | LMNAGPR139F7NR1H4PLAU | |
| SCHEMBL7344055 | 0.88 | F7 (0.46) | GPR139F7SMN1; SMN2F2 | |
| SCHEMBL7341087 | 0.88 | GPR139 (0.48) | LMNAGPR139F7ITGB3KMT2A | |
| SCHEMBL7338356 | 0.88 | SMN1; SMN2 (0.44) | HTTLMNAMAPK1GPR139F7 | |
| SCHEMBL7341726 | 0.87 | GPR139 (0.42) | LMNAGPR139F7ITGB3KMT2A | |
| SCHEMBL7832122 | 0.86 | ITGB3 (0.42) | PKMHTTMAPK1GPR139F7 | |
| SCHEMBL7345189 | 0.86 | F2 (0.42) | GPR139F7PLAUITGB3ITGA2B | |
| SCHEMBL7339148 | 0.85 | F7 (0.44) | HTTLMNAGPR139F7ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |