Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.88 |
| ▸ | MPO | P05164 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837922 | 0.94 | HTR1A (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL7844899 | 0.87 | HTR1A (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL7844041 | 0.80 | HTR1A (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL2403826 | 0.78 | MPO (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL2405001 | 0.77 | MPO (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL13938361 | 0.77 | HTR1A (0.69) | HTR1ASLC6A4MPO | |
| SCHEMBL7836687 | 0.76 | HTR1A (1.00) | HTR1ASLC6A4MPO | |
| SCHEMBL20441315 | 0.76 | MPO (0.67) | HTR1ASLC6A4MPO | |
| SCHEMBL14075529 | 0.76 | HTR1A (0.60) | HTR1ASLC6A4MPO | |
| SCHEMBL2407287 | 0.76 | MPO (1.00) | HTR1ASLC6A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |