SCHEMBL7837553

SCHEMBL7837553

COc1cc2c(cc1OC)N(Cc1ccccc1Cl)C(=O)C(NC(=O)OC(C)(C)C)C2

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
XIAP P98170 12/20 0.45
NPY1R P25929 1/20 0.42
BCHE P06276 1/20 0.41
ACHE P22303 1/20 0.41
HDAC6 Q9UBN7 2/20 0.39
CCKBR P32239 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7848691 0.87 XIAP (0.46) XIAPNPY1RCCKBR
SCHEMBL7837557 0.84 XIAP (0.40) XIAPNPY1RCCKBR
SCHEMBL7836155 0.78 AADAT (0.52) BCHEACHEHDAC6
Hydrochloric Acid SCHEMBL8476250 0.78 AADAT (0.51) BCHEACHEHDAC6
SCHEMBL5132571 0.74 NPY1R (0.59) XIAPNPY1RCCKBR
SCHEMBL7416762 0.74 NPY1R (0.59) XIAPNPY1RCCKBR
SCHEMBL7417336 0.74 NPY1R (0.51) XIAPNPY1RCCKBR
SCHEMBL5651533 0.74 NPY1R (0.52) XIAPNPY1RHDAC6
SCHEMBL5132457 0.74 NPY1R (0.52) XIAPNPY1R
SCHEMBL649566 0.74 NPY1R (0.52) XIAPNPY1RHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0802922-B1 NOVEL AMINO ACID DERIVATIVES, METHOD OF PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM PHARMA (DE) 2001-09-26 EP disclosed
US-5922878-A NEUROKININ(TACHYKININ) ANTAGONIST FOR RESPIRATORY SYSTEM DISORDERSS FOR TREATMENT OF ASTHMA, SKIN DISORDERS OR ANTIINFLAMMATORY AGENTS BOEHRINGER INGELHEIM GMBH (DE) 1999-07-13 US disclosed
US-5712397-A NEUROKININ ANTAGONISTS BOEHRINGER INGELHEIM GMBH (DE) 1998-01-27 US disclosed
EP-0802922-A1 NOVEL AMINO ACID DERIVATIVES, METHOD OF PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1997-10-29 EP disclosed
WO-1995023810-A1 NOVEL AMINO ACID DERIVATIVES, METHOD OF PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1995-09-08 WO disclosed