Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 14/20 | 0.62 |
| ▸ | ABCC8 | Q09428 | 14/20 | 0.62 |
| ▸ | KCNJ11 | Q14654 | 14/20 | 0.62 |
| ▸ | KCNJ8 | Q15842 | 14/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.61 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GALK1 | P51570 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836378 | 0.92 | FFAR3 (0.56) | ABCC9ABCC8KCNJ11KCNJ8FFAR3 | |
| SCHEMBL6910550 | 0.88 | FFAR3 (0.53) | ABCC9ABCC8KCNJ11KCNJ8FFAR3 | |
| SCHEMBL7836425 | 0.82 | KDM4E (0.68) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL3323782 | 0.82 | FFAR3 (0.71) | FFAR3GAAKDM4E | |
| SCHEMBL7824118 | 0.81 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7837406 | 0.81 | FFAR3 (0.53) | ABCC9ABCC8KCNJ11KCNJ8FFAR3 | |
| SCHEMBL7820460 | 0.80 | GPR174 (0.74) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7836312 | 0.80 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7835461 | 0.80 | ABCC9 (0.74) | ABCC9ABCC8KCNJ11KCNJ8FFAR3 | |
| SCHEMBL7820668 | 0.80 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8GPR174 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665834-B1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ASTRAZENECA AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| EP-0539154-B1 | Acridine-1,8-dione-derivatives as therapeutic agents | ZENECA LTD (GB) | 1997-12-29 | — | — | EP | disclosed |
| US-5622964-A | ADMINISTERING 4,6,7,8-TETRAHYDRO-5(1H)-QUINOLONE DERIVATIVE TO TREAT ASTHMA IN MAMMALS | ZENECA LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5484792-A | DRUGS FOR TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1996-01-16 | — | — | US | disclosed |
| US-5455253-A | For urinary incontinence | ZENECA LIMITED (GB) | 1995-10-03 | — | — | US | disclosed |
| EP-0665834-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1995-08-09 | — | — | EP | disclosed |
| US-5340819-A | Method for treating urinary incontinence using 9-(3-nitrophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H) acridinedione | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-08-23 | — | — | US | disclosed |
| WO-1994008966-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |
| EP-0539154-A1 | Acridine-1,8-dione-derivatives as therapeutic agents | ZENECA LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |