Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1D | Q01668 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GPR174 | Q9BXC1 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837751 | 0.83 | KMT2A (0.48) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL2451845 | 0.79 | CACNA1D (0.69) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL7838059 | 0.70 | MEN1 (0.51) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL7817258 | 0.70 | GPR174 (0.72) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL8876634 | 0.69 | ALDH1A1 (0.58) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL2443968 | 0.68 | CACNA1D (0.57) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL7833823 | 0.67 | CACNA1D (0.52) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL15976552 | 0.66 | ALDH1A1 (0.74) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL7835486 | 0.66 | KMT2A (0.52) | CACNA1DALDH1A1MEN1KMT2AGPR174 | |
| SCHEMBL7823758 | 0.66 | ABCC9 (0.53) | CACNA1DALDH1A1MEN1KMT2AGPR174 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665834-B1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ASTRAZENECA AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| US-5622964-A | ADMINISTERING 4,6,7,8-TETRAHYDRO-5(1H)-QUINOLONE DERIVATIVE TO TREAT ASTHMA IN MAMMALS | ZENECA LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5455253-A | For urinary incontinence | ZENECA LIMITED (GB) | 1995-10-03 | — | — | US | disclosed |
| WO-1994008966-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |