Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 4/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837592 | 0.75 | FNTA (0.45) | FNTAFNTBEP300NR1H4PGGT1B | |
| Hydrochloric Acid SCHEMBL7834494 | 0.74 | FNTA (0.44) | FNTAFNTBEP300NR1H4PGGT1B | |
| SCHEMBL6913123 | 0.71 | TRIM24 (0.35) | FNTAFNTBDPP4TRIM24CYP19A1 | |
| SCHEMBL7668376 | 0.68 | SLC6A4 (0.44) | TRIM24CYP19A1TRIM33 | |
| SCHEMBL7826547 | 0.66 | CYP19A1 (0.46) | FNTAFNTBCYP19A1PGGT1B | |
| SCHEMBL444433 | 0.64 | FNTA (0.50) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8161653 | 0.64 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL7577164 | 0.63 | BRD4 (0.38) | TRIM24CYP19A1KDM4EGAAMAPT | |
| SCHEMBL2713004 | 0.62 | KDM4E (0.49) | GRM2KDM4E | |
| SCHEMBL6224361 | 0.61 | NPC1 (0.50) | KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891350-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0891350-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036889-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |