Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27585500 | 0.82 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1CYP2C9ALDH1A1 | |
| SCHEMBL24768169 | 0.78 | LTA4H (0.59) | CYP11B1CYP11B2CYP19A1CYP2C9SMN1; SMN2 | |
| SCHEMBL28131051 | 0.76 | LTA4H (0.60) | SMN1; SMN2ALDH1A1LMNAKDM4ELTA4H | |
| SCHEMBL9869024 | 0.76 | CYP11B1 (0.49) | CYP11B1CYP11B2NOD2CYP19A1CYP2C9 | |
| SCHEMBL27924299 | 0.75 | CYP17A1 (0.67) | CYP19A1CYP2C9SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29670400 | 0.75 | FTO (0.48) | CYP11B1CYP11B2NOD2CYP19A1CYP2C9 | |
| SCHEMBL9869425 | 0.75 | CYP11B1 (0.48) | CYP11B1CYP11B2NOD2CYP19A1CYP2C9 | |
| SCHEMBL3840431 | 0.73 | LTA4H (0.50) | SMN1; SMN2ALDH1A1LMNALTA4HSLC5A1 | |
| SCHEMBL15325999 | 0.72 | SLC5A2 (0.51) | SMN1; SMN2ALDH1A1LMNALTA4HSLC5A1 | |
| SCHEMBL30416680 | 0.71 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904080-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-0904080-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859015-A | N-heterocyclic piperazinyl and H-heterocyclic piperazinonyl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997036592-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |