Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869024 | 0.87 | CYP11B1 (0.49) | CYP11B1CYP11B2CYP19A1CYP2C9FTO | |
| SCHEMBL9868800 | 0.86 | KDM6B (0.41) | CYP11B1CYP11B2FTOLMNASMN1; SMN2 | |
| SCHEMBL29670400 | 0.81 | FTO (0.48) | CYP11B1CYP11B2CYP19A1CYP2C9FTO | |
| SCHEMBL27585500 | 0.76 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1CYP2C9FTO | |
| SCHEMBL7837599 | 0.75 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1CYP2C9FTO | |
| SCHEMBL9868876 | 0.74 | FTO (0.50) | CYP11B1CYP11B2CYP2C9FTOLMNA | |
| SCHEMBL24768169 | 0.72 | LTA4H (0.59) | CYP11B1CYP11B2CYP19A1CYP2C9FTO | |
| SCHEMBL6269745 | 0.70 | KDM4E (0.48) | FTOLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27924299 | 0.69 | CYP17A1 (0.67) | CYP19A1CYP2C9LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL22189692 | 0.69 | L3MBTL1 (0.56) | LMNAALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |