SCHEMBL7837825

SCHEMBL7837825

C=CCOc1nc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
HIF1A Q16665 1/20 0.32
PPOX P50336 5/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7594681 0.88 HRH4 (0.36)
SCHEMBL7657743 0.84 AGPAT2 (0.32)
SCHEMBL7594678 0.84
SCHEMBL29190282 0.82 DHODH (0.31) HTT
SCHEMBL28991747 0.81 PPOX (0.40) MEN1KMT2APPOXLMNAMAPT
SCHEMBL8543133 0.80 PPOX (0.46) HTTSMN1; SMN2PPOX
SCHEMBL29435264 0.79 KAT2B (0.36) MEN1KMT2APPOXLMNAMAPT
SCHEMBL7595081 0.79 GAA (0.32) MEN1KMT2A
SCHEMBL29435262 0.79 GAA (0.32) MEN1KMT2A
SCHEMBL19641780 0.79 GAA (0.32) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076655-A1 N-PYRIDONYL HERBICIDES Novartis AG (CH) 2001-02-21 EP disclosed
WO-1999052893-A1 N-PYRIDONYL HERBICIDES NOVARTIS AG (CH) 1999-10-21 WO disclosed