Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 12/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145121 | 0.76 | GBA1 (0.61) | HRH3KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8298485 | 0.76 | BRS3 (0.60) | BRS3HRH3 | |
| Hydrochloric Acid SCHEMBL4577505 | 0.75 | GBA1 (0.59) | HRH3KDM1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL23410114 | 0.73 | GBA1 (0.58) | HRH3KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7919393 | 0.73 | BRS3 (0.62) | BRS3HRH3 | |
| SCHEMBL8106523 | 0.73 | BRS3 (0.54) | BRS3HRH3KDM1AMAOBAKT1 | |
| SCHEMBL7841577 | 0.72 | NOS2 (0.47) | BRS3KDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8105207 | 0.72 | BRS3 (0.53) | BRS3HRH3MAOB | |
| Hydrochloric Acid SCHEMBL8521500 | 0.72 | BRS3 (0.61) | BRS3HRH3 | |
| SCHEMBL8115077 | 0.72 | BRS3 (0.47) | BRS3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | claimed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | claimed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | claimed |
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |