Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837029 | 0.89 | MMP1 (0.34) | HPGDALDH1A1KMT2AMAPK1GAA | |
| SCHEMBL7848659 | 0.86 | MMP1 (0.35) | HPGDALDH1A1SMN1; SMN2KMT2AGAA | |
| SCHEMBL7843343 | 0.84 | HPGD (0.46) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7960589 | 0.84 | HPGD (0.46) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6221034 | 0.83 | MMP1 (0.38) | MMP1MMP13 | |
| SCHEMBL7849870 | 0.82 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7849871 | 0.82 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7847971 | 0.80 | HPGD (0.47) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7835338 | 0.80 | MMP1 (0.37) | MMP1MMP13 | |
| SCHEMBL7840445 | 0.80 | MMP1 (0.46) | MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |