Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 8/20 | 0.42 |
| ▸ | MMP3 | P08254 | 7/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983815 | 0.89 | MMP1 (0.41) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL4290067 | 0.88 | MMP2 (0.41) | MMP1MMP2MMP3EPHX2 | |
| SCHEMBL6942326 | 0.86 | MMP1 (0.39) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6940058 | 0.85 | CTSK (0.38) | MMP1MMP13MMP2MMP3 | |
| SCHEMBL6221034 | 0.84 | MMP1 (0.38) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6986871 | 0.83 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL7835338 | 0.83 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL7478743 | 0.83 | MMP2 (0.39) | MMP1MMP2MMP3 | |
| SCHEMBL7960600 | 0.82 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL7828836 | 0.82 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |