Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843343 | 0.90 | HPGD (0.46) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7960589 | 0.90 | HPGD (0.46) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7845190 | 0.89 | L3MBTL1 (0.41) | SMN1; SMN2MMP1MMP3MMP9 | |
| SCHEMBL7845187 | 0.89 | L3MBTL1 (0.41) | SMN1; SMN2MMP1MMP3MMP9 | |
| SCHEMBL7849870 | 0.88 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7849871 | 0.88 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7953806 | 0.86 | MMP1 (0.41) | HPGDMEN1KMT2AMMP1MMP3 | |
| SCHEMBL7953804 | 0.86 | MMP1 (0.41) | HPGDMEN1KMT2AMMP1MMP3 | |
| SCHEMBL7839640 | 0.80 | HPGD (0.41) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7853162 | 0.76 | MMP1 (0.46) | MEN1KMT2AMMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |