Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595921 | 0.88 | GABRA1 (0.63) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL5504619 | 0.86 | KDM4E (0.69) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL38662825 | 0.83 | KDM4E (0.63) | KDM4EHPGDMAPTHSD17B10ALDH1A1 | |
| SCHEMBL2730788 | 0.82 | KDM4E (0.56) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL27389076 | 0.82 | KDM4E (0.56) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL12133099 | 0.81 | TRPM8 (0.57) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL27371374 | 0.80 | ALDH1A1 (0.56) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL25904024 | 0.79 | ALDH1A1 (0.68) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL18222533 | 0.79 | TRPM8 (0.69) | KDM4EHPGDMAPTHSD17B10LMNA | |
| SCHEMBL3389079 | 0.78 | TRPM8 (0.61) | KDM4EHPGDMAPTHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |