Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10103070 | 0.84 | ACHE (0.34) | BRD4CREBBP | |
| SCHEMBL9749565 | 0.74 | KDM4E (0.47) | ESR1ESR2TTRKDM4EALDH1A1 | |
| SCHEMBL5547664 | 0.74 | BRD4 (0.55) | ESR1ESR2TTRKDM4EALDH1A1 | |
| SCHEMBL19194418 | 0.68 | ESR1 (0.61) | ESR1ESR2TTRKDM4EALDH1A1 | |
| SCHEMBL5548009 | 0.67 | MEN1 (0.46) | ESR1ESR2KDM4EALDH1A1CYP3A4 | |
| SCHEMBL2183040 | 0.67 | ESR2 (0.51) | ESR1ESR2TTRKDM4EALDH1A1 | |
| SCHEMBL9749669 | 0.66 | ESR1 (0.43) | ESR1ESR2TTRKDM4EALDH1A1 | |
| SCHEMBL9749055 | 0.65 | ESR1 (0.61) | ESR1ESR2CHRNA7 | |
| SCHEMBL15447322 | 0.65 | KDM4E (0.47) | ESR1ESR2TTRKDM4EALDH1A1 | |
| SCHEMBL2182284 | 0.65 | KDM4E (0.47) | ESR1ESR2TTRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785424-B2 | ngCycloartanone derivatives with anticancer activity | PIERRE FABRE MEDICAMENT (FR) | 2014-07-22 | — | — | US | disclosed |
| WO-2010133687-A1 | CYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | PIERRE FABRE MEDICAMENT (FR) | 2010-11-25 | — | — | WO | disclosed |