Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564351 | 1.00 | NOS2 (0.50) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL30052597 | 0.89 | NOS2 (0.42) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL146828 | 0.87 | NOS2 (0.46) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL995604 | 0.87 | NOS2 (0.46) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL6859669 | 0.87 | NOS2 (0.46) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL9737609 | 0.83 | NOS2 (0.43) | NOS2NOS3NOS1GLI1DPP4 | |
| Phthalic Acid SCHEMBL6322396 | 0.83 | ELANE (0.44) | NOS2NOS3NOS1DPP4DPP8 | |
| Phthalic Acid SCHEMBL5424564 | 0.83 | ELANE (0.44) | NOS2NOS3NOS1DPP4DPP8 | |
| SCHEMBL31298402 | 0.82 | NOS2 (0.42) | NOS2NOS3NOS1GLI1DPP4 | |
| SCHEMBL28288006 | 0.82 | NOS2 (0.42) | NOS2NOS3NOS1GLI1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959882-A4 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | HAMILTON GREGORY S (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0959882-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998029117-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-07-09 | — | — | WO | disclosed |