Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838256 | 0.88 | NPC1 (0.43) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7842966 | 0.85 | MAPT (0.47) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7839101 | 0.84 | PDE4D (0.42) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7838638 | 0.83 | NPC1 (0.47) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL8160295 | 0.83 | ALDH1A1 (0.41) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7841971 | 0.83 | TAS1R3 (0.41) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7842210 | 0.82 | KDM4E (0.46) | KDM4EHSD17B10GAAMEN1KMT2A | |
| SCHEMBL7840763 | 0.81 | TAS1R3 (0.41) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7841575 | 0.81 | HTT (0.40) | KDM4EHSD17B10GAAMAPTMEN1 | |
| SCHEMBL7838632 | 0.80 | L3MBTL1 (0.49) | KDM4EHSD17B10GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882030-B1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GMBH (DE) | 2001-09-12 | — | — | EP | disclosed |
| US-6197800-B1 | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MI BESCHRAENKTER HAFTUNG (DE) | 2001-03-06 | — | — | US | disclosed |
| US-6017939-A | 2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |