Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 5/20 | 0.54 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11669913 | 0.99 | KDM4E (0.56) | KDM4ESLC2A1BCHEPDCD1CD274 | |
| Bromide SCHEMBL11670771 | 0.99 | KDM4E (0.56) | KDM4ESLC2A1BCHEPDCD1CD274 | |
| SCHEMBL4643754 | 0.90 | CTSV (0.56) | KDM4EBCHEPDCD1CD274POLB | |
| SCHEMBL10646744 | 0.84 | ALDH1A1 (0.51) | KDM4EPDCD1CD274POLBMEN1 | |
| SCHEMBL3599069 | 0.82 | POLB (0.54) | POLBMEN1KMT2AALDH1A1CTSV | |
| SCHEMBL5642071 | 0.82 | CTSV (0.56) | PDCD1CD274POLBMEN1KMT2A | |
| SCHEMBL6814063 | 0.82 | POLB (0.54) | PDCD1CD274POLBMEN1KMT2A | |
| SCHEMBL7279743 | 0.82 | SLC2A1 (0.80) | KDM4ESLC2A1BCHEMEN1KMT2A | |
| SCHEMBL6235952 | 0.81 | PDCD1 (0.51) | KDM4ESLC2A1BCHEPDCD1CD274 | |
| Hydrochloric Acid SCHEMBL7839532 | 0.81 | POLB (0.53) | POLBMEN1KMT2AALDH1A1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558677-B1 | BIOLOGICALLY ACTIVE AMINES | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5763465-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1998-06-09 | — | — | US | disclosed |
| US-5648370-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-07-15 | — | — | US | disclosed |
| WO-1992008708-A1 | BIOLOGICALLY ACTIVE AMINES | FISONS PLC (GB) | 1992-05-29 | — | — | WO | disclosed |
| US-4024281-A | N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines | SMITHKLINE CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3933913-A | N,N'-bis[3-substituted-4-hydroxypheyl)-2-hydroxyethyl)]-polymethylenediamines | SMITHKLINE CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |