Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 12/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847344 | 1.00 | REN (0.35) | RENBCHENAAAMMP1MMP3 | |
| SCHEMBL7843485 | 0.87 | MMP1 (0.41) | BCHEMMP1MMP3 | |
| SCHEMBL7843490 | 0.87 | MMP1 (0.41) | BCHEMMP1MMP3 | |
| SCHEMBL7953804 | 0.80 | MMP1 (0.41) | RENMMP1MMP3 | |
| SCHEMBL7953806 | 0.80 | MMP1 (0.41) | RENMMP1MMP3 | |
| SCHEMBL7836878 | 0.80 | REN (0.38) | RENBCHEMMP1MMP3 | |
| SCHEMBL7836876 | 0.80 | REN (0.38) | RENBCHEMMP1MMP3 | |
| SCHEMBL6943422 | 0.78 | BCHE (0.39) | RENBCHEMMP3 | |
| SCHEMBL7764176 | 0.78 | BCHE (0.39) | RENBCHEMMP3 | |
| SCHEMBL6943418 | 0.78 | BCHE (0.39) | RENBCHEMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |