Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953806 | 1.00 | MMP1 (0.41) | MMP1MMP3MMP9MMP13REN | |
| SCHEMBL7845187 | 0.88 | L3MBTL1 (0.41) | MMP1MMP3MMP9 | |
| SCHEMBL7845190 | 0.88 | L3MBTL1 (0.41) | MMP1MMP3MMP9 | |
| SCHEMBL7847971 | 0.86 | HPGD (0.47) | MMP1MMP3MMP9POLBMAPT | |
| SCHEMBL7955742 | 0.85 | MMP1 (0.49) | MMP1MMP3MMP9MMP13MMP8 | |
| SCHEMBL7955739 | 0.85 | MMP1 (0.49) | MMP1MMP3MMP9MMP13MMP8 | |
| SCHEMBL7946725 | 0.83 | MMP1 (0.42) | MMP1MMP3MMP9MMP13MMP8 | |
| SCHEMBL7946723 | 0.83 | MMP1 (0.42) | MMP1MMP3MMP9MMP13MMP8 | |
| SCHEMBL7827850 | 0.81 | MMP1 (0.46) | MMP1MMP3MMP9MMP13REN | |
| SCHEMBL7853162 | 0.81 | MMP1 (0.46) | MMP1MMP3MMP9MMP13REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |