Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | LITAF | Q99732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7851036 | 0.88 | ALDH1A1 (0.37) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL7503528 | 0.85 | ADRB2 (0.40) | TOP2ATOP2BADRB2 | |
| SCHEMBL7841318 | 0.85 | TOP2A (0.55) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL6217926 | 0.81 | TOP2A (0.45) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL10915183 | 0.81 | TOP2A (0.43) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL7851458 | 0.79 | ALDH1A1 (0.47) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL6213861 | 0.79 | TOP2A (0.52) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL9044178 | 0.79 | TOP2A (0.47) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL10927140 | 0.79 | TOP2A (0.45) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL7843532 | 0.78 | ADRB2 (0.54) | TOP2ATOP2BPOLBKMT2AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |