Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 12/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217926 | 0.90 | TOP2A (0.45) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL10585828 | 0.89 | TOP2A (0.52) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL6217010 | 0.86 | ALDH1A1 (0.45) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL10875673 | 0.85 | TOP2A (0.41) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL10631361 | 0.85 | TOP2A (0.61) | TOP2ATOP2BKCNH2POLBALDH1A1 | |
| SCHEMBL10927107 | 0.84 | ALDH1A1 (0.48) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL10925284 | 0.84 | KCNH2 (0.46) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL6212483 | 0.84 | TOP2A (0.49) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL10875216 | 0.84 | TOP2A (0.41) | TOP2ATOP2BKCNH2ADRB2POLB | |
| SCHEMBL10648280 | 0.83 | LMNA (0.44) | TOP2ATOP2BKCNH2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181588-A2 | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, process for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-05-21 | — | — | EP | claimed |
| EP-0181588-A2 | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, process for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-05-21 | — | — | EP | disclosed |