Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21072556 | 0.75 | NOS3 (0.47) | NPSR1KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL5820179 | 0.75 | NPSR1 (0.42) | NPSR1TSHRKDM4EALDH1A1GAA | |
| SCHEMBL22439846 | 0.75 | NPSR1 (0.47) | NPSR1TSHRKDM4EALDH1A1GAA | |
| SCHEMBL7665937 | 0.75 | AGXT (0.44) | NPSR1TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL1840938 | 0.73 | NPSR1 (0.43) | NPSR1TSHRKDM4EALDH1A1GAA | |
| SCHEMBL289542 | 0.71 | OPRK1 (0.44) | NPSR1ATM | |
| SCHEMBL18124754 | 0.71 | ATM (0.47) | NPSR1TSHRKDM4EALDH1A1GAA | |
| SCHEMBL12248189 | 0.71 | NPSR1 (0.47) | NPSR1TSHRKDM4EALDH1A1GAA | |
| SCHEMBL26684922 | 0.71 | NPSR1 (0.38) | NPSR1TSHRKDM4EALDH1A1GAA | |
| SCHEMBL25581894 | 0.70 | NPSR1 (0.50) | NPSR1KDM4EALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805812-B1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5792767-A | TREATMENT OF BENIGN PROSTATIC HYPERTROPY | ABBOTT LABORATORIES (US) | 1998-08-11 | — | — | US | disclosed |