Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 11/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748923 | 0.76 | RAB9A (0.50) | LMNAPOLBSMN1; SMN2S1PR5GBA2 | |
| SCHEMBL7406503 | 0.76 | GBA2 (0.49) | LMNAPOLBSMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL2170278 | 0.76 | GBA2 (0.49) | LMNAPOLBSMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL7478389 | 0.76 | GBA2 (0.49) | LMNAPOLBSMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL7672219 | 0.76 | RAB9A (0.50) | LMNAPOLBSMN1; SMN2S1PR5GBA2 | |
| SCHEMBL5491802 | 0.76 | RAB9A (0.50) | LMNAPOLBSMN1; SMN2S1PR5GBA2 | |
| SCHEMBL355693 | 0.76 | SMN1; SMN2 (0.58) | LMNAPOLBSMN1; SMN2S1PR5L3MBTL1 | |
| SCHEMBL8089152 | 0.75 | GAA (0.33) | POLBL3MBTL1ALDH1A1GAACHRM2 | |
| SCHEMBL29948421 | 0.74 | GAA (0.41) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL28037367 | 0.73 | POLB (0.35) | POLBSMN1; SMN2S1PR5S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |