Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | ATF4 | P18848 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiourea SCHEMBL28331572 | 0.81 | ALOX15 (0.55) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL5707393 | 0.81 | ADAMTS5 (0.48) | RAB9AALDH1A1ATF4POLBMAPT | |
| SCHEMBL5039308 | 0.79 | MAOB (0.51) | KDM4EALDH1A1PKMAPOBEC3GMAPT | |
| SCHEMBL7846467 | 0.79 | WDR5 (0.44) | ALDH1A1POLBMAPTMAOBGAA | |
| SCHEMBL1816835 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9ANPC1ALDH1A1ATF4 | |
| SCHEMBL4100035 | 0.79 | WDR5 (0.66) | SMN1; SMN2RAB9ANPC1ATF4CYP1A2 | |
| SCHEMBL159433 | 0.78 | ALOX15 (0.56) | ALDH1A1MAOBGAA | |
| Hydrochloric Acid SCHEMBL5480598 | 0.78 | WDR5 (0.63) | SMN1; SMN2RAB9ANPC1ATF4CYP1A2 | |
| SCHEMBL7842545 | 0.77 | WDR5 (0.70) | SMN1; SMN2KDM4EALDH1A1HTTPOLB | |
| SCHEMBL3740206 | 0.77 | NPC1 (0.63) | RAB9ANPC1KDM4EALDH1A1ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886810-A | Indoline compound and preparation method and application thereof | 徐州医科大学 | 2024-04-16 | — | — | CN | disclosed |
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |
| US-4001447-A | HAVING HYPOLIPEMIANT, VASODILATATORY AND HYPOCHOLESTEROLEMIANT ACTIVITIES | ROUSSEL-UCLAF (FR) | 1977-01-04 | — | — | US | disclosed |