Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845483 | 0.81 | CA1 (0.48) | ALDH1A1NPC1RAB9AMAOAMAOB | |
| SCHEMBL7846468 | 0.79 | MAPT (0.38) | ALDH1A1MAOBMAPTLMNAHPGD | |
| SCHEMBL16392373 | 0.79 | KMT2A (0.47) | ALDH1A1NPC1RAB9AMAOAMAOB | |
| SCHEMBL5670691 | 0.71 | EPHX1 (0.42) | ALDH1A1NPC1RAB9AMAOAMAOB | |
| SCHEMBL4689285 | 0.71 | MEN1 (0.45) | ALDH1A1MAPTKDM4ELMNAHPGD | |
| SCHEMBL4599074 | 0.71 | ALDH1A1 (0.42) | ALDH1A1RAB9AMAPTPOLBLMNA | |
| SCHEMBL27617217 | 0.67 | MAOA (0.43) | ALDH1A1NPC1RAB9AMAOAMAOB | |
| SCHEMBL10189868 | 0.67 | EPHX1 (0.60) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL216629 | 0.66 | KMT2A (0.46) | MAOAMAOBMAPTLMNAHPGD | |
| SCHEMBL10506141 | 0.66 | KMT2A (0.45) | ALDH1A1NPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |
| US-4001447-A | HAVING HYPOLIPEMIANT, VASODILATATORY AND HYPOCHOLESTEROLEMIANT ACTIVITIES | ROUSSEL-UCLAF (FR) | 1977-01-04 | — | — | US | disclosed |