Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 8/20 | 0.34 |
| ▸ | QPCT | Q16769 | 7/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663787 | 0.91 | PDE4B (0.42) | PDK1GSK3BQPCTPDE4BPDE4D | |
| SCHEMBL7656438 | 0.90 | CAMK2D (0.42) | CAMK2DGSK3B | |
| SCHEMBL7655234 | 0.87 | CAMK2D (0.40) | CAMK2DGSK3BCNR2 | |
| SCHEMBL7666393 | 0.87 | CAMK2D (0.36) | DYRK1ACAMK2DPDK1GSK3BQPCT | |
| SCHEMBL7653829 | 0.87 | CNR2 (0.36) | DYRK1ACAMK2DPDK1GSK3BQPCT | |
| SCHEMBL7657833 | 0.86 | MAOB (0.36) | MEN1KMT2APDE4BPDE4D | |
| SCHEMBL7657867 | 0.85 | BDKRB2 (0.34) | CAMK2DGSK3BPDE4BPDE4D | |
| SCHEMBL8365260 | 0.85 | CAMK2D (0.41) | CAMK2DGSK3BQPCTMEN1MAPK1 | |
| SCHEMBL7851518 | 0.81 | PPARG (0.36) | DYRK1ACNR2MEN1KMT2ALMNA | |
| SCHEMBL8515897 | 0.81 | CAMK2D (0.44) | CAMK2DGSK3BQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |