Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 13/20 | 0.80 |
| ▸ | PRKCA | P17252 | 12/20 | 0.80 |
| ▸ | PRKCE | Q02156 | 9/20 | 0.80 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842285 | 0.89 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7838393 | 0.89 | PRKCB (0.76) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7838411 | 0.89 | PRKCB (0.80) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841721 | 0.88 | PRKCA (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7845203 | 0.86 | PRKCB (0.67) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7842615 | 0.86 | PRKCB (0.94) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7831266 | 0.86 | PRKCB (0.66) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841274 | 0.85 | PRKCB (0.68) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841534 | 0.84 | PRKCB (0.72) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7832574 | 0.84 | PRKCB (0.72) | PRKCBPRKCAPRKCEJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | claimed |
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | disclosed |