Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 12/20 | 0.94 |
| ▸ | PRKCA | P17252 | 12/20 | 0.94 |
| ▸ | PRKCE | Q02156 | 9/20 | 0.94 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | JAK1 | P23458 | 1/20 | 0.68 |
| ▸ | TYK2 | P29597 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 2/20 | 0.65 |
| ▸ | CDK4 | P11802 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | PRKACG | P22612 | 1/20 | 0.60 |
| ▸ | PRKACB | P22694 | 1/20 | 0.60 |
| ▸ | CCND1 | P24385 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842285 | 0.97 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7840914 | 0.92 | PRKCB (0.87) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7845445 | 0.88 | PRKCB (0.84) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7830883 | 0.88 | PRKCB (0.80) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7843214 | 0.86 | PRKCA (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841762 | 0.86 | PRKCB (0.80) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7838411 | 0.86 | PRKCB (0.80) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7830800 | 0.85 | PRKCA (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7841465 | 0.85 | PRKCB (0.96) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7839539 | 0.84 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | claimed |
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | disclosed |