Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931831 | 0.80 | HPGD (0.40) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL28110878 | 0.76 | MAPT (0.45) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL3783249 | 0.71 | CHRNB2 (0.45) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL1950379 | 0.71 | HTT (0.59) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL28531388 | 0.69 | HTT (0.49) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL18929951 | 0.69 | MAPT (0.42) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL22797004 | 0.68 | CYP11B2 (0.54) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL30623522 | 0.68 | HTT (0.56) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL30441248 | 0.68 | HTT (0.56) | MAPTGAAHSD17B10ALDH1A1RECQL | |
| SCHEMBL7532910 | 0.67 | CHRNB2 (0.56) | CYP2A6CYP3A4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839144-B1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL GMBH (DE) | 2001-09-19 | — | — | EP | claimed |