Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401532 | 0.84 | SIGMAR1 (0.38) | SIGMAR1OPRD1 | |
| SCHEMBL2764645 | 0.84 | SIGMAR1 (0.38) | SIGMAR1OPRD1CHRM5CHRM3CA12 | |
| SCHEMBL8387444 | 0.71 | GSR (0.42) | SIGMAR1 | |
| SCHEMBL28958643 | 0.70 | OPRD1 (0.40) | SIGMAR1OPRD1CHRM5CHRM3CA12 | |
| SCHEMBL30903250 | 0.70 | SLC6A4 (0.41) | — | |
| SCHEMBL8310688 | 0.69 | SIGMAR1 (0.41) | SIGMAR1OPRD1CHRM5CHRM3CA12 | |
| SCHEMBL1077282 | 0.69 | SIGMAR1 (0.38) | SIGMAR1OPRD1CHRM5CHRM3CA12 | |
| SCHEMBL28252629 | 0.68 | SLC6A4 (0.37) | — | |
| SCHEMBL1905214 | 0.68 | SIGMAR1 (0.47) | SIGMAR1CA12CA1CA2CA9 | |
| SCHEMBL9801277 | 0.67 | SLC6A4 (0.32) | SIGMAR1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071668-A1 | 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | Du Pont Pharmaceuticals Company (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999054308-A1 | 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-10-28 | — | — | WO | disclosed |