Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840910 | 0.90 | MAPT (0.36) | MAPTTP53EDNRAPOLBALDH1A1 | |
| SCHEMBL9088949 | 0.85 | MAPT (0.38) | MAPTTP53EDNRAPOLBALDH1A1 | |
| SCHEMBL6640093 | 0.85 | EDNRA (0.44) | MAPTTP53EDNRAPOLBBRD4 | |
| SCHEMBL4773317 | 0.83 | MAPT (0.36) | MAPTTP53EDNRAPOLBALDH1A1 | |
| SCHEMBL8351866 | 0.82 | EDNRA (0.50) | MAPTTP53EDNRA | |
| SCHEMBL8348292 | 0.81 | EDNRA (0.48) | MAPTTP53EDNRA | |
| SCHEMBL6772184 | 0.81 | EDNRA (0.38) | MAPTTP53EDNRA | |
| SCHEMBL6640800 | 0.81 | EDNRB (0.41) | MAPTTP53EDNRA | |
| SCHEMBL9089818 | 0.80 | EDNRA (0.37) | MAPTTP53EDNRA | |
| SCHEMBL6770127 | 0.80 | EDNRA (0.41) | MAPTTP53EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | disclosed |