Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 6/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842618 | 0.90 | MAPT (0.38) | MAPTTP53EDNRAPOLBALDH1A1 | |
| SCHEMBL4765130 | 0.83 | MAPT (0.34) | MAPTTP53EDNRAALDH1A1 | |
| SCHEMBL8784249 | 0.79 | EDNRA (0.47) | EDNRA | |
| SCHEMBL8784337 | 0.78 | EDNRA (0.39) | EDNRA | |
| SCHEMBL4769236 | 0.78 | EDNRA (0.38) | MAPTTP53EDNRA | |
| SCHEMBL5530252 | 0.76 | TP53 (0.32) | MAPTTP53EDNRA | |
| SCHEMBL4767237 | 0.76 | EDNRB (0.39) | EDNRA | |
| SCHEMBL9088949 | 0.76 | MAPT (0.38) | MAPTTP53EDNRAPOLBALDH1A1 | |
| SCHEMBL6970298 | 0.75 | EDNRA (0.38) | EDNRAALDH1A1 | |
| SCHEMBL5787828 | 0.75 | EDNRA (0.37) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | disclosed |