Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797403 | 0.75 | KDM4E (0.41) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL14360472 | 0.75 | MAPK13 (0.39) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL7833299 | 0.73 | PTGS2 (0.47) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL6505614 | 0.71 | PTGS2 (0.66) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL7832748 | 0.71 | PTGS2 (0.66) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL7842143 | 0.71 | PTGS2 (0.58) | KDM4ELMNAMAPTXBP1MAPK1 | |
| SCHEMBL7833390 | 0.71 | PTGS2 (0.62) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL7844983 | 0.71 | PTGS2 (0.62) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL6514789 | 0.71 | PTGS2 (0.60) | KDM4ELMNAMAPTXBP1MAPK1 | |
| SCHEMBL7843817 | 0.70 | PTGS2 (0.67) | KDM4EMAPTNPSR1PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |