Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14360472 | 0.76 | MAPK13 (0.39) | KDM4ERAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL7842727 | 0.75 | MAPK13 (0.40) | KDM4ESMN1; SMN2ALDH1A1HPGDMAPK13 | |
| SCHEMBL8797404 | 0.72 | TDP2 (0.35) | KDM4ERAB9ASMN1; SMN2SREBF2NPC1 | |
| SCHEMBL4866814 | 0.70 | ALDH1A1 (0.59) | KDM4ERAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL10967586 | 0.64 | ABL1 (0.55) | KDM4ERAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL28327240 | 0.64 | KDM4E (0.86) | KDM4ERAB9ASMN1; SMN2SREBF2NPC1 | |
| SCHEMBL17014757 | 0.62 | AR (0.69) | KDM4ERAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL14996562 | 0.62 | ADORA3 (0.40) | KDM4ERAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL10810267 | 0.62 | MAPT (0.59) | RAB9ASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL4875896 | 0.61 | ABL1 (0.70) | KDM4ERAB9ASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |