Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797404 | 0.77 | TDP2 (0.35) | TDP2BACE1 | |
| SCHEMBL7844544 | 0.68 | PTGS2 (0.45) | — | |
| SCHEMBL7833305 | 0.68 | PTGS2 (0.41) | — | |
| SCHEMBL7841008 | 0.67 | PTGS2 (0.59) | — | |
| SCHEMBL7832883 | 0.67 | PTGS2 (0.55) | — | |
| SCHEMBL7832752 | 0.67 | PTGS2 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7843825 | 0.66 | PTGS2 (0.55) | — | |
| SCHEMBL7846633 | 0.66 | PTGS2 (0.43) | — | |
| SCHEMBL7842727 | 0.66 | MAPK13 (0.40) | — | |
| SCHEMBL7842651 | 0.65 | PTGS2 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |