Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 9/20 | 1.00 |
| ▸ | JAK3 | P52333 | 10/20 | 0.70 |
| ▸ | PRKCA | P17252 | 1/20 | 0.70 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.68 |
| ▸ | JAK1 | P23458 | 4/20 | 0.61 |
| ▸ | JAK2 | O60674 | 4/20 | 0.61 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830740 | 0.89 | PRKCB (0.80) | PRKCBJAK3PRKCAJAK1JAK2 | |
| SCHEMBL5819295 | 0.85 | PRKCB (0.74) | PRKCBJAK3PRKCASTK10SLK | |
| SCHEMBL7831655 | 0.85 | PRKCB (1.00) | PRKCBJAK3PRKCAJAK1JAK2 | |
| SCHEMBL7832745 | 0.84 | PRKCB (0.72) | PRKCBJAK3PRKCASTK10SLK | |
| SCHEMBL7840226 | 0.84 | PRKCB (0.72) | PRKCBJAK3PRKCASTK10SLK | |
| SCHEMBL31060142 | 0.83 | PRKCB (1.00) | PRKCBJAK3PRKCASTK10SLK | |
| SCHEMBL7840920 | 0.83 | PRKCB (1.00) | PRKCBJAK3PRKCASTK10SLK | |
| SCHEMBL7841740 | 0.83 | PRKCB (0.79) | PRKCBJAK3PRKCAJAK1JAK2 | |
| SCHEMBL7841411 | 0.83 | PRKCB (1.00) | PRKCBJAK3PRKCASTK10SLK | |
| SCHEMBL7841496 | 0.83 | PRKCB (0.75) | PRKCBJAK3PRKCAJAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | claimed |
| WO-2013029043-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2013-02-28 | — | — | WO | disclosed |
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | disclosed |
| JP-2000109479-A | DI-SUBSTITUTED MALEIMIDE COMPOUND, AND ITS USE AS MEDICINE | JAPAN TOBACCO INC | 2000-04-18 | — | — | JP | disclosed |