SCHEMBL7832745

SCHEMBL7832745

COc1ccc(NC2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c(OC)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCB P05771 9/20 0.72
STK10 O94804 5/20 0.71
SLK Q9H2G2 5/20 0.71
PRKCA P17252 1/20 0.60
FLT3 P36888 2/20 0.56
MKNK1 Q9BUB5 1/20 0.56
MKNK2 Q9HBH9 1/20 0.56
KDR P35968 3/20 0.56
CDK4 P11802 2/20 0.56
CCND1 P24385 2/20 0.56
PLK4 O00444 1/20 0.56
AURKA O14965 1/20 0.56
NUAK1 O60285 1/20 0.56
ABL1 P00519 1/20 0.56
EGFR P00533 1/20 0.56
ERBB2 P04626 1/20 0.56
INSR P06213 1/20 0.56
IGF1R P08069 1/20 0.56
MET P08581 1/20 0.56
PDGFRB P09619 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7840226 0.90 PRKCB (0.72) PRKCBSTK10SLKPRKCAFLT3
SCHEMBL7842735 0.84 PRKCB (1.00) PRKCBSTK10SLKPRKCAJAK3
SCHEMBL5819295 0.81 PRKCB (0.74) PRKCBSTK10SLKPRKCAKDR
SCHEMBL7815879 0.80 CDK4 (0.73) PRKCBPRKCAFLT3KDRCDK4
SCHEMBL9085267 0.80 CDK4 (0.87) PRKCBPRKCAFLT3KDRCDK4
SCHEMBL7844170 0.78 PRKCB (1.00) PRKCBPRKCACDK4CCND1ABL1
SCHEMBL7842177 0.76 PRKCB (0.72) PRKCBPRKCACDK4CCND1ABL1
SCHEMBL7840920 0.76 PRKCB (1.00) PRKCBSTK10SLKPRKCACDK4
SCHEMBL31060142 0.76 PRKCB (1.00) PRKCBSTK10SLKPRKCACDK4
SCHEMBL7825879 0.75 KDR (0.76) PRKCBPRKCAFLT3KDRCDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1120414-A1 DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF JAPAN TOBACCO INC. (JP) 2001-08-01 EP claimed
WO-2013029043-A1 SELECTIVE KINASE INHIBITORS REACTION BIOLOGY CORP. (US) 2013-02-28 WO disclosed
WO-2013028664-A1 PSMA IMAGING AGENTS SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2013-02-28 WO disclosed
EP-1120414-A1 DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF JAPAN TOBACCO INC. (JP) 2001-08-01 EP disclosed