Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23343631 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL7055657 | 0.85 | MRGPRX4 (0.63) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL2436356 | 0.84 | PPARA (0.50) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL5328114 | 0.83 | MRGPRX4 (0.51) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL825947 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL23987214 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL2193058 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| SCHEMBL5752927 | 0.81 | MRGPRX4 (0.53) | SMN1; SMN2TP53MRGPRX4RAB9ANPC1 | |
| Methyl 3-Methoxybenzoate SCHEMBL384913 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2TP53RAB9ANPC1POLB | |
| SCHEMBL2436534 | 0.80 | L3MBTL1 (0.65) | SMN1; SMN2TP53RAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010016657-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. | 2001-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010016657-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | INA, GRIN2C, GRIN2A | SMN1; SMN2 1323/4885TP53 4518/4885MRGPRX4 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.