Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91361 | 0.82 | ADRB2 (0.49) | ADRB2HTR6SPRKDM4EHPGD | |
| SCHEMBL1048933 | 0.81 | ADRB2 (0.48) | ADRB2HTR6SPRKDM4EHPGD | |
| SCHEMBL13962818 | 0.81 | ADRB2 (0.48) | ADRB2HTR6SPRKDM4EHPGD | |
| SCHEMBL13962816 | 0.81 | ADRB2 (0.48) | ADRB2HTR6SPRKDM4EHPGD | |
| SCHEMBL8243638 | 0.77 | HTR2A (0.61) | KDM4EHPGDHSD17B10LMNAALDH1A1 | |
| SCHEMBL2807459 | 0.72 | ADRB2 (0.41) | ADRB2HTR6SPRKDM4EMTNR1A | |
| SCHEMBL5710420 | 0.71 | ADRB2 (0.40) | ADRB2HTR6SPRKDM4EHPGD | |
| SCHEMBL78477 | 0.71 | HTR1D (0.66) | HTR6HTR1DMAPTHTR2A | |
| SCHEMBL23604756 | 0.71 | LMNA (0.40) | ADRB2HTR6KDM4EHPGDHSD17B10 | |
| SCHEMBL1049675 | 0.70 | ADRB2 (0.37) | ADRB2HTR6SPRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |