SCHEMBL7842850

SCHEMBL7842850

CCCCCCCCCCOC(=O)c1cnc(-c2ccc3cc(OCc4ccccc4)ccc3c2)nc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.46
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46
MAPK1 P28482 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TLR4 O00206 1/20 0.46
TLR2 O60603 1/20 0.46
CNR2 P34972 1/20 0.46
PLA2G2D Q9UNK4 1/20 0.46
MAOB P27338 2/20 0.45
MEN1 O00255 1/20 0.45
HSP90AA1 P07900 1/20 0.45
KMT2A Q03164 1/20 0.45
LMNA P02545 1/20 0.45
MRGPRX4 Q96LA9 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7841771 0.87 MAOB (0.58) L3MBTL1MAOBMEN1HSP90AA1KMT2A
SCHEMBL7839312 0.86 PLA2G2D (0.42) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL9343609 0.86 ALDH1A1 (0.53) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL6657816 0.86 ALDH1A1 (0.53) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL7841191 0.86 ALOX5 (0.49) CYP3A4PLA2G2DMRGPRX4
SCHEMBL7841558 0.86 ALOX5 (0.49) CYP3A4PLA2G2DMRGPRX4
SCHEMBL6650525 0.85 TSHR (0.54) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL7837951 0.84 ESR1 (0.49) ALDH1A1TSHRMAPK1CNR2MEN1
SCHEMBL7092341 0.84 RARB (0.52) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL8376618 0.82 RARB (0.60) ALDH1A1CYP3A4TSHRMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751133-B1 Pyrimidine compound, and liquid crystal composition and liquid crystal element using the same MITSUI CHEMICALS INC (JP) 2001-09-12 EP disclosed
US-5770108-A HIGH SPEED RESPONSE, MOLECULAR ORIENTATION, HIGH CONTRAST, RECEPTIVITY MITSUI TOATSU CHEMICALS, INC. (JP) 1998-06-23 US disclosed
EP-0751133-A1 Pyrimidine compound, and liquid crystal composition and liquid crystal element using the same MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1997-01-02 EP disclosed