Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 3/20 | 0.47 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.47 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299175 | 0.95 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| Trifluoromethanesulfonic Acid SCHEMBL29356486 | 0.86 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBGAASIRT1 | |
| SCHEMBL8177534 | 0.84 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL9727370 | 0.84 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL7419507 | 0.83 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL29557286 | 0.83 | SIRT1 (0.53) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL774746 | 0.82 | LCK (0.55) | ALDH1A1SMN1; SMN2HPGDGAAPDE5A | |
| SCHEMBL1030124 | 0.81 | PI4KB (0.50) | ALDH1A1SMN1; SMN2KMT2AHPGDGAA | |
| SCHEMBL2175797 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2KMT2AHPGDGAA | |
| SCHEMBL5481490 | 0.81 | CCNE1 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984963-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| US-6162808-A | Compounds | ASTRAZENECA U.K. LIMITED (GB) | 2000-12-19 | — | — | US | disclosed |