Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801720 | 0.89 | PTGS2 (0.42) | PTGS2PTGS1RAB9AMAPTKMT2A | |
| SCHEMBL7843634 | 0.89 | PTGS2 (0.55) | PTGS2PTGS1RAB9AKMT2APPARD | |
| SCHEMBL7842015 | 0.87 | PTGS2 (0.55) | PTGS2PTGS1RAB9AMAPTKMT2A | |
| SCHEMBL7840792 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1RAB9AMAPTPPARD | |
| SCHEMBL7844231 | 0.84 | MAPT (0.43) | PTGS2RAB9AMAPTKMT2AGRM5 | |
| SCHEMBL7844744 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1RAB9AMAPTPPARD | |
| SCHEMBL6246548 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL7833526 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1GRM5PPARDALOX5 | |
| SCHEMBL7847200 | 0.79 | MAPT (0.40) | PTGS2PTGS1RAB9AMAPTKMT2A | |
| SCHEMBL7842600 | 0.79 | PTGS2 (0.65) | PTGS2PTGS1PPARDALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |