Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 12/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801720 | 0.91 | PTGS2 (0.42) | MAPTPPARDPTGS2FFAR1GRM5 | |
| SCHEMBL7844228 | 0.87 | PTGS2 (0.57) | PPARDPTGS2 | |
| SCHEMBL7843368 | 0.84 | PTGS2 (0.42) | MAPTPPARDPTGS2FFAR1GRM5 | |
| SCHEMBL7843555 | 0.83 | PTGS2 (0.51) | PPARDPTGS2NPC1RAB9AKMT2A | |
| SCHEMBL7841302 | 0.83 | PTGS2 (0.51) | PPARDPTGS2NPC1RAB9AKMT2A | |
| SCHEMBL7833567 | 0.82 | PTGS2 (0.56) | PPARDPTGS2PPARGPPARAL3MBTL1 | |
| SCHEMBL7844271 | 0.80 | PTGS2 (0.53) | PPARDPTGS2GRM5NPC1RAB9A | |
| SCHEMBL7840138 | 0.80 | PTGS2 (0.53) | PPARDPTGS2GRM5NPC1RAB9A | |
| SCHEMBL7840172 | 0.80 | PTGS2 (0.48) | PPARDPTGS2NPC1RAB9AKMT2A | |
| SCHEMBL7842156 | 0.80 | PTGS2 (0.48) | PPARDPTGS2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |